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| Research Application |
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genetic research |
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| BRC No. 01834_B6-Tg(CAG-FLPe)36 |
FLP-FRT system: Floxed mice can be generated after excision of neo (selective marker gene) by crossing with FLP Tg mice. |
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| The FLP-FRT system is similar to the cre-loxP system and is useful for more complex dual approaches that combine FLP with other recombinases, such as Cre and ΦC31..
FLPe is a variant of the FLP recombinase with a higher enzymatic activity at 37°C.
This transgenic mouse of C57BL/6 strain expresses the FLPe recombinase under the control of the CAG promoter.
This strain can be used as 'FLP deleter' mouse by crossing with the other genetically-engineered mice that have a pair of FLP recombinase target (FRT) sequence flanking the genomic region of interest. |
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