A Japanese wild-derived inbred strain for functional genomics MSM/MsRbrc RBRC00209

Gen : F49 +F56

MSM (RBRC00209) is a wild-derived inbred strain originated from Japanese wild mice, Mus musculus molossinus [1]. The MSM mice have several unique phenotypes, such as small body size (<15 grams), low incidence of tumor development, and distinct behaviors, making them promising resources for higher brain functions and lifestyle-related diseases by expanding genome diversity. The MSM is especially invaluable for uncovering novel functions of the genome by the availability of the MSM genomic BAC libraries [2], whole genome sequence information [3], microsatellite marker data [4], consomic strains with C57BL/6 background [5], and germ cell competent ES cells [6]. Thus, the MSM expands the range of the genetic variations of laboratory mouse strains.

Depositor : Professor Toshihiko Shiroishi, Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka-ken 411-8540, Japan.

Reference : 1. Moriwaki, K., et al. 2009. Exp Anim. 58:123-134. 2. Abe, K., et al. 2004. Genome Research. 14: 2439-2447. 3. http://molossinus.lab.nig.ac.jp/msmdb/ 4. http://www.shigen.nig.ac.jp/mouse/mmdbj/top.jsp 5. Takada, T., et al. 2008. Genome Research. 18: 500-508. (http://molossinus.lab.nig.ac.jp/phenotype/index.html) 6. Araki, K., et al. 2009. Mamm Genome. 20:14-20.