Dopamine receptor knockout mice

B6.129S-Drd1a<tm1Mok> RBRC 01080

Figure 1. Equipment for measurement of homecage activity and food/water intake. Figure 2. The homecage activity of D1 dopamine receptor knockout (D1R KO) mice is significantly higher than that of wild-type (WT) mice. Each point represents the mean ± S.E.M. of total activity counted over 24 hours (p<0.001, Mann-Whitney U test).

Dopamine, a principal neurotransmitter, is distributed in most parts of the central nervous system (CNS) and is required by a number of major neural systems of the brain, mediating locomotor activity (nigrostantial system), motivated behavior (mesolimbic system), and learning and memory (mesocortical system). Impairment in the nigrostriatal pathway contributes to dysfunctional movement, a common symptom in Parkinson's disease. The dopamine D1 receptor (Drd1) knockout mouse was generated to specify the functional role of Drd1 in behavioral and neural responses to prediction of reward. The knockout mice of other dopamine receptor subtypes (see Related strains) are also available for study of the biological functions of the dopaminergic system.

Related strain : B6.129S-Drd2<tmlMok> RBRC01081 B6.129S-Drd3<tmlMok> RBRC01082 B6.129S-Drd4<tmlMok> RBRC01083 B6.129S-Drd5<tmlMok> RBRC01084 B6.129-Drd4<tmlMok> RBRC02341 B6.129-Drd5<tmlMok> RBRC02335 Depositor : Dr. Toshikuni Sasaoka, National Institute for Basic Biology Reference : 1. Anh Hai Tran et al. Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty. J. Neurosci 28: 13390-13400, 2008 2. Anh Hai Tran et al. Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. PNAS 102:2117-2122, 2005. 3. Anh Hai Tran et al. Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice. PNAS 99: 8986-8991, 2002.