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HLA Antigen List
HLA Class I
| Antigen |
Allele |
RDB No. |
Name of Clone |
Frequency in Japanese population |
| freq.1 (%) |
freq.2 (%) |
freq.3 (%) |
freq.4 (%) |
| HLA-A1 |
A*0101 | 3368 |
Human HLA-A*0101 cDNA |
1.8 |
0.2 |
0.57 |
0.25 |
| HLA-A2 |
A*0206 | 2867 |
Human HLA-A*0206 cDNA |
8.4 |
10.4 |
8.99 |
8.74 |
| HLA-A2 |
A*0207 | 2868 |
Human HLA-A*0207 cDNA |
4.0 |
3.4 |
2.87 |
3.39 |
| HLA-A2 |
A*02011 | 2866 |
Human HLA-A*02011 cDNA |
10.6 |
10.9 |
10.71 |
11.64 |
| HLA-A3 |
A*0301 | 3367 |
Human HLA-A*0301 cDNA |
r |
0.8 |
0.57 |
0.25 |
| HLA-A11 |
A*11011 | 2869 |
Human HLA-A*11011 cDNA |
11.1 |
8.1 |
10.71 |
10.22 |
| HLA-A24 |
| 1176 |
pA01 |
|
|
|
|
| HLA-A24 |
A*24021 | 2871 |
Human HLA-A*24021 cDNA |
32.7 |
35.6 |
36.52 |
36.20 |
| HLA-A24 |
A*2420 | 3365 |
Human HLA-A*2420 cDNA |
vr |
vr |
|
0.83 |
| HLA-A26 |
A*2601 | 2870 |
Human HLA-A*2601 cDNA |
6.2 |
9.8 |
11.28 |
7.66 |
| HLA-A26 |
A*2603 | 3366 |
Human HLA-A*2603 cDNA |
1.3 |
2.1 |
1.91 |
1.47 |
| HLA-A31 |
A*31012 | 2872 |
Human HLA-A*31012 cDNA |
9.3 |
7.7 |
6.88 |
9.14 |
| HLA-A33 |
A*3303 | 2873 |
Human HLA-A*3303 cDNA |
12.8 |
7.9 |
7.84 |
6.68
|
| |
98.2 |
96.9 |
98.85 |
96.47 |
| HLA-B7 |
B*07021 | 2874 |
Human HLA-B*07021 cDNA |
5.2 |
5.2 |
3.63 |
5.70 |
| HLA-B8 |
B*0801 | 3369 |
Human HLA-B*0801 cDNA |
|
|
|
|
| HLA-B15 |
B*15011 | 2875 |
Human HLA-B*15011 cDNA |
6.5 |
7.2 |
9.37 |
7.51 |
| HLA-B35 |
B*35011 | 2876 |
Human HLA-B*35011 cDNA |
7.8 |
8.6 |
8.80 |
7.76 |
| HLA-B38 |
B*3801 | 3370 |
Human HLA-B*3801 cDNA |
|
|
|
|
| HLA-B39 |
B*39011 | 3371 |
Human HLA-B*39011 cDNA |
3.5 |
r |
4.02 |
3.44 |
| HLA-B40 |
B*40012 | 2877 |
Human HLA-B*40012 cDNA |
6.1 |
5.1 |
5.35 |
5.40 |
| HLA-B40 |
B*4002 | 2878 |
Human HLA-B*4002 cDNA |
6.1 |
8.2 |
8.41 |
8.25 |
| HLA-B44 |
B*4401 | 1178 |
AM2.60 |
|
|
|
|
| HLA-B44 |
B*44031 | 2879 |
Human HLA-B*44031 cDNA |
12.2 |
6.9 |
6.69 |
6.24 |
| HLA-B46 |
B*4601 | 2880 |
Human HLA-B*4601 cDNA |
6.1 |
3.8 |
3.44 |
4.96 |
| HLA-B48 |
B*4801 | 3372 |
Human HLA-B*4801 cDNA |
4.3 |
2.7 |
5.54 |
2.65 |
| HLA-B51 |
B*51011 | 2881 |
Human HLA-B*51011 cDNA |
7.0 |
7.9 |
6.88 |
8.35 |
| HLA-B52 |
B*52011 | 2882 |
Human HLA-B*52011 cDNA |
10.4 |
13.7 |
0.19 |
10.90 |
| HLA-B54 |
B*5401 | 3373 |
Human HLA-B*5401 cDNA |
7.0 |
6.5 |
7.07 |
8.79 |
| HLA-B55 |
B*5502 | 3374 |
Human HLA-B*5502 cDNA |
2.2 |
3.2 |
2.87 |
1.92 |
| HLA-B55 |
| 1180 |
pB55 |
|
|
|
|
| HLA-B59 |
B*5901 | 3375 |
Human HLA-B*5901 cDNA |
0.9 |
1.7 |
1.72 |
1.96
|
| |
85.3 |
80.7 |
73.98 |
83.83 |
| HLA-Cw1 |
Cw*0102 | 2883 |
Human HLA-Cw*0102 cDNA |
17.0 |
|
16.63 |
|
| HLA-Cw1 |
Cw*0103 | 3376 |
Human HLA-Cw*0103 cDNA |
r |
|
|
|
| HLA-Cw3 |
Cw*03031 | 2884 |
Human HLA-Cw*03031 cDNA |
7.8 |
|
13.19 |
|
| HLA-Cw3 |
Cw*03041 | 2885 |
Human HLA-Cw*03041 cDNA |
11.3 |
|
13.77 |
|
| HLA-Cw4 |
Cw*04011 | 2886 |
Human HLA-Cw*04011 cDNA |
6.5 |
|
4.40 |
|
| HLA-Cw6 |
Cw*0602 | 3377 |
Human HLA-Cw*0602 cDNA |
1.7 |
|
1.34 |
|
| HLA-Cw7 |
Cw*0702 | 2887 |
Human HLA-Cw*0702 cDNA |
11.3 |
|
10.33 |
|
| HLA-Cw8 |
Cw*0801 | 2888 |
Human HLA-Cw*0801 cDNA |
10.9 |
|
9.75 |
|
| HLA-Cw12 |
Cw*12022 | 2889 |
Human HLA-Cw*12022 cDNA |
10.4 |
|
11.09 |
|
| HLA-Cw14 |
Cw*14021 | 3378 |
Human HLA-Cw*14021 cDNA |
5.7 |
|
4.78 |
|
| HLA-Cw14 |
Cw*1403 | 2890 |
Human HLA-Cw*1403 cDNA |
12.2 |
|
7.07 |
|
| HLA-Cw15 |
Cw*15021 | 3379 |
Human HLA-Cw*15021 cDNA |
1.7 |
|
4.40 |
|
| HLA-Cx 52 (Cw 12) |
Cw*1201 | 1177 |
pAC201 |
|
|
|
|
| HLA-Cx52 (Cw12) |
Cw*1201 | 1179 |
pC68 |
|
|
|
|
| |
96.5 |
|
96.75 |
|
| HLA-G |
| 1246 |
HLA-G.7.0 E |
|
|
|
|
Freq.1: frequency in Japanese population (N=117), Tokunaga K. et al. Immunogenetics 1997; 46(3)199-205.
Freq.2: frequency in Japanese population (N=493), Tanaka H. et al. Clinical Transplants 1996; 139-144.
Freq.3: frequency in Japanese population (N=523), Nakajima, et al. MHC Vol.8 No.1 p1-32.
Freq.4: frequency in Japanese population (N=1018), Azuma F., et al., MHC, p166, 2004.
r: rare; vr: very rare.
HLA Class II
| Antigen |
Allele |
RDB No. |
Name of Clone |
| HLA DR beta 5 |
|
1222 |
TOK H5 DR beta |
| HLA-DR beta 4 |
|
1223 |
YT158 |
| HLA-DQA1 |
|
1227 |
pgDQ4A |
| HLA-DQB1 |
|
1228 |
pg DQ1B |
| HLA-DQB1 |
|
1230 |
pg DQ1BS |
| HLA-DRA |
|
1232 |
DRA2EH |
| HLA-DPA1 |
|
1233 |
DPA 02022 |
| HLA-DPB1 |
|
1234 |
DPB0202 |
| HLA-DRB1 |
|
1235 |
K^b DRB1 0803 |
| HLA-DRB1 |
|
1236 |
K^b DRB1 1201 |
| HLA-DRB1 |
|
1237 |
K^b DRB1 1302 |
| HLA-DRB3 |
|
1238 |
DRB30301 EMJ-4 |
| HLA-DQA1 |
|
1239 |
DQA10501 AMALA-4 |
| HLA-DQB1 |
|
1240 |
DQB10301 AMALA-4 |
| HLA-DQA1 |
|
1241 |
DQA10101 KAS116 3-6 |
| HLA-DQB1 |
|
1242 |
DQB10503 EK2-4 |

REFERENCES FOR HLA
Akatsuka Y., Morishima Y., Kuzushima K., Kodera Y., Takahashi T. (2007) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
Cancer Science 98 (8): 1139-1146.
Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T. (2004) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
Br. J. Haematol. 124 (5): 629-635.
Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. (2003) Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens.
J. Exp. Med. 197 (11): 1489-1500.
Akatsuka Y, Goldberg TA, Kondo E, Martin EG, Obata Y, Morishima Y, Takahashi T, Hansen JA (2002) Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines.
Tissue Antigens, 59 (6): 502-511.
Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T. (2002) Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest.
Transplantation, 74: 1773-1780.
Ando H, Miyata Y, Takata H, Inoko H. (1993) Identification of alloantisera reacting with HLA-C blank (Cx52) using a mouse L-cell transfected with the HLA-Cw*1201 allele.
Hum Immunol. 36 (2): 76-80
Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. (1992) Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
Immunogenetics 36 (5): 319-325.
Zemmour J, Parham P. (1991) HLA class I nucleotide sequences, 1991.
Tissue Antigens 37 (4): 174-180. Erratum in: Tissue Antigens. 1992 Nov;40(5):221-228.
Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants.
Eu.r J Immunol. 21 (10): 2341-2347.
Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) HLA-DQ-restricted CD4+ T cells specific to streptococcal antigen present in low but not in high responders.
J Immunol. 146 (8): 2560-2567.
Tamaki J. (1992)[Analysis of polymorphism at the human class I MHC locus, HLA-G]
Hokkaido Igaku Zasshi (Hokkaido J. Med. Sci.) 67 (5): 583-594. Japanese.
Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. (1990) Expression of the human MHC, HLA-DQW6 genes alters the immune response in C57BL/6 mice.
J Immunol. 1990 Jul 1;145(1):353-60.
Takata H, Inoko H, Ando A, Haranaka M, Watanabe B, Tsuji K, Iri H. (1988) Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52.
Immunogenetics 28 (4): 265-270.

2004.08.23
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