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HLA Antigen List


HLA Class I

Antigen Allele RDB No. Name of Clone Frequency in Japanese population
freq.1 (%) freq.2 (%) freq.3 (%) freq.4 (%)
HLA-A1 A*01013368 Human HLA-A*0101 cDNA 1.8 0.2 0.57 0.25
HLA-A2 A*02062867 Human HLA-A*0206 cDNA 8.4 10.4 8.99 8.74
HLA-A2 A*02072868 Human HLA-A*0207 cDNA 4.0 3.4 2.87 3.39
HLA-A2 A*020112866 Human HLA-A*02011 cDNA 10.6 10.9 10.71 11.64
HLA-A3 A*03013367 Human HLA-A*0301 cDNA r 0.8 0.57 0.25
HLA-A11 A*110112869 Human HLA-A*11011 cDNA 11.1 8.1 10.71 10.22
HLA-A24  1176 pA01        
HLA-A24 A*240212871 Human HLA-A*24021 cDNA 32.7 35.6 36.52 36.20
HLA-A24 A*24203365 Human HLA-A*2420 cDNA vr vr   0.83
HLA-A26 A*26012870 Human HLA-A*2601 cDNA 6.2 9.8 11.28 7.66
HLA-A26 A*26033366 Human HLA-A*2603 cDNA 1.3 2.1 1.91 1.47
HLA-A31 A*310122872 Human HLA-A*31012 cDNA 9.3 7.7 6.88 9.14
HLA-A33 A*33032873 Human HLA-A*3303 cDNA 12.8 7.9 7.84 6.68
  98.2 96.9 98.85 96.47
HLA-B7 B*070212874 Human HLA-B*07021 cDNA 5.2 5.2 3.63 5.70
HLA-B8 B*08013369 Human HLA-B*0801 cDNA        
HLA-B15 B*150112875 Human HLA-B*15011 cDNA 6.5 7.2 9.37 7.51
HLA-B35 B*350112876 Human HLA-B*35011 cDNA 7.8 8.6 8.80 7.76
HLA-B38 B*38013370 Human HLA-B*3801 cDNA        
HLA-B39 B*390113371 Human HLA-B*39011 cDNA 3.5 r 4.02 3.44
HLA-B40 B*400122877 Human HLA-B*40012 cDNA 6.1 5.1 5.35 5.40
HLA-B40 B*40022878 Human HLA-B*4002 cDNA 6.1 8.2 8.41 8.25
HLA-B44 B*44011178 AM2.60        
HLA-B44 B*440312879 Human HLA-B*44031 cDNA 12.2 6.9 6.69 6.24
HLA-B46 B*46012880 Human HLA-B*4601 cDNA 6.1 3.8 3.44 4.96
HLA-B48 B*48013372 Human HLA-B*4801 cDNA 4.3 2.7 5.54 2.65
HLA-B51 B*510112881 Human HLA-B*51011 cDNA 7.0 7.9 6.88 8.35
HLA-B52 B*520112882 Human HLA-B*52011 cDNA 10.4 13.7 0.19 10.90
HLA-B54 B*54013373 Human HLA-B*5401 cDNA 7.0 6.5 7.07 8.79
HLA-B55 B*55023374 Human HLA-B*5502 cDNA 2.2 3.2 2.87 1.92
HLA-B55  1180 pB55        
HLA-B59 B*59013375 Human HLA-B*5901 cDNA 0.9 1.7 1.72 1.96
  85.3 80.7 73.98 83.83
HLA-Cw1 Cw*01022883 Human HLA-Cw*0102 cDNA 17.0   16.63  
HLA-Cw1 Cw*01033376 Human HLA-Cw*0103 cDNA r      
HLA-Cw3 Cw*030312884 Human HLA-Cw*03031 cDNA 7.8   13.19  
HLA-Cw3 Cw*030412885 Human HLA-Cw*03041 cDNA 11.3   13.77  
HLA-Cw4 Cw*040112886 Human HLA-Cw*04011 cDNA 6.5   4.40  
HLA-Cw6 Cw*06023377 Human HLA-Cw*0602 cDNA 1.7   1.34  
HLA-Cw7 Cw*07022887 Human HLA-Cw*0702 cDNA 11.3   10.33  
HLA-Cw8 Cw*08012888 Human HLA-Cw*0801 cDNA 10.9   9.75  
HLA-Cw12 Cw*120222889 Human HLA-Cw*12022 cDNA 10.4   11.09  
HLA-Cw14 Cw*140213378 Human HLA-Cw*14021 cDNA 5.7   4.78  
HLA-Cw14 Cw*14032890 Human HLA-Cw*1403 cDNA 12.2   7.07  
HLA-Cw15 Cw*150213379 Human HLA-Cw*15021 cDNA 1.7   4.40  
HLA-Cx 52 (Cw 12) Cw*12011177 pAC201        
HLA-Cx52 (Cw12) Cw*12011179 pC68        
  96.5   96.75  
HLA-G  1246 HLA-G.7.0 E        

Freq.1: frequency in Japanese population (N=117), Tokunaga K. et al. Immunogenetics 1997; 46(3)199-205.
Freq.2: frequency in Japanese population (N=493), Tanaka H. et al. Clinical Transplants 1996; 139-144.
Freq.3: frequency in Japanese population (N=523), Nakajima, et al. MHC Vol.8 No.1 p1-32.
Freq.4: frequency in Japanese population (N=1018), Azuma F., et al., MHC, p166, 2004.
r: rare; vr: very rare.


HLA Class II

Antigen Allele RDB No. Name of Clone
HLA DR beta 5   1222 TOK H5 DR beta
HLA-DR beta 4   1223 YT158
HLA-DQA1   1227 pgDQ4A
HLA-DQB1   1228 pg DQ1B
HLA-DQB1   1230 pg DQ1BS
HLA-DRA   1232 DRA2EH
HLA-DPA1   1233 DPA 02022
HLA-DPB1   1234 DPB0202
HLA-DRB1   1235 K^b DRB1 0803
HLA-DRB1   1236 K^b DRB1 1201
HLA-DRB1   1237 K^b DRB1 1302
HLA-DRB3   1238 DRB30301 EMJ-4
HLA-DQA1   1239 DQA10501 AMALA-4
HLA-DQB1   1240 DQB10301 AMALA-4
HLA-DQA1   1241 DQA10101 KAS116 3-6
HLA-DQB1   1242 DQB10503 EK2-4


REFERENCES FOR HLA

Akatsuka Y., Morishima Y., Kuzushima K., Kodera Y., Takahashi T. (2007) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
Cancer Science 98 (8): 1139-1146.

Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T. (2004) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
Br. J. Haematol. 124 (5): 629-635.

Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. (2003) Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens.
J. Exp. Med. 197 (11): 1489-1500.

Akatsuka Y, Goldberg TA, Kondo E, Martin EG, Obata Y, Morishima Y, Takahashi T, Hansen JA (2002) Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines.
Tissue Antigens, 59 (6): 502-511.

Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T. (2002) Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest.
Transplantation, 74: 1773-1780.

Ando H, Miyata Y, Takata H, Inoko H. (1993) Identification of alloantisera reacting with HLA-C blank (Cx52) using a mouse L-cell transfected with the HLA-Cw*1201 allele.
Hum Immunol. 36 (2): 76-80

Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. (1992) Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
Immunogenetics 36 (5): 319-325.

Zemmour J, Parham P. (1991) HLA class I nucleotide sequences, 1991.
Tissue Antigens 37 (4): 174-180. Erratum in: Tissue Antigens. 1992 Nov;40(5):221-228.

Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants.
Eu.r J Immunol. 21 (10): 2341-2347.

Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) HLA-DQ-restricted CD4+ T cells specific to streptococcal antigen present in low but not in high responders.
J Immunol. 146 (8): 2560-2567.

Tamaki J. (1992)[Analysis of polymorphism at the human class I MHC locus, HLA-G]
Hokkaido Igaku Zasshi (Hokkaido J. Med. Sci.) 67 (5): 583-594. Japanese.

Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. (1990) Expression of the human MHC, HLA-DQW6 genes alters the immune response in C57BL/6 mice.
J Immunol. 1990 Jul 1;145(1):353-60.

Takata H, Inoko H, Ando A, Haranaka M, Watanabe B, Tsuji K, Iri H. (1988) Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52.
Immunogenetics 28 (4): 265-270.



2004.08.23